Faculty of Health Sciences - sbf@gelisim.edu.tr
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 Faculty of Health Sciences - sbf@gelisim.edu.tr

Occupational Therapy








 Rett Syndrome and the Importance of Occupational Therapy Interventions: An Evidence-Based Perspective


Rett syndrome is a rare neurodevelopmental disorder that primarily affects girls and persists throughout life. It is associated with mutations in the MECP2 gene and was first described by Andreas Rett in 1966. After an apparently typical early development, children begin to show regression between 6 and 18 months of age, with loss of motor and hand skills, repetitive stereotypical hand movements, impaired communication, and balance difficulties. These clinical features significantly affect daily functioning for both the child and the family.


Although there is currently no definitive cure for Rett syndrome, multidisciplinary rehabilitation approaches have been shown to bring meaningful improvements in quality of life. Among these, occupational therapy plays a key role by supporting participation in daily activities.

Occupational therapy interventions aim to maximize independence in self-care tasks such as eating, dressing, and hygiene. Motor-focused activities help regulate muscle tone, maintain mobility, and improve balance and coordination. Additionally, sensory integration approaches are frequently used to address the sensory sensitivities commonly observed in children with Rett syndrome, enabling them to engage more effectively with their environment.

Participation in play and education is another important domain of occupational therapy. Play-based interventions strengthen hand–eye coordination and social interaction skills, while educational adaptations—including assistive tools, appropriate seating, and environmental modifications—facilitate active participation in learning processes.

Support is not limited to the child alone; occupational therapists also work closely with families and schools. Parents are guided in implementing strategies that ease daily routines, while home and school environments are adapted to ensure safety, accessibility, and greater independence. Such interventions not only enhance the child’s functioning but also reduce the caregiving burden on families.

Recent studies emphasize that early occupational therapy interventions preserve functional abilities, promote social participation, and help prevent secondary complications in individuals with Rett syndrome. For this reason, occupational therapy should be considered a central component in the long-term management of the disorder.